Vitamin D3 and Inflammation
Vitamin D deficiency has become a global health problem that leads to metabolic bone disease and many other inflammatory illnesses. A recently published study investigated the safety and effectiveness of a single high dose of vitamin D3 (80,000 IU) on vitamin D and systemic inflammation status in healthy females.
Fifty healthy females were recruited and orally supplemented with a single vitamin D3 bolus (80,000 IU) daily for 30 days. Serum 25(OH)D3 (the established vitamin D3 metabolite in the human body) significantly increased one and thirty days after supplementation when compared with baseline. The concentrations of the measured proinflammatory markers decreased at the end of the study period compared to the baseline levels. The authors concluded that a single high dose (80,000 IU) is effective in rapidly and safely improving serum vitamin D and inflammation status in healthy females.
Singaporeans were found to be slightly deficient in vitamin D. It is quite astonishing considering that we are living in a tropical climate. With the recent discovery of the healty benefits of vitamin D and deleterious effects of its inadequacy, we may need to seek dietary and supplementary sources of this important nutrient.
 Alsufiani, Hadeil M., AlGhamdi, Shareefa A., AlShaibi, Huda F., Khoja, Sawsan O., Saif, Safa F. & Carlberg, Carsten. 2022. A Single Vitamin D3 Bolus Supplementation Improves Vitamin D Status and Reduces Proinflammatory Cytokines in Healthy Females. Nutrients 14: 3963.