The Omega-3 Index and Alzheimer Disease
Simply put, the omega-3 index is the percentage of total omega-3 fatty acids from the total fatty acids in blood. Over the past 2 decades, several major observational cohorts reported associations between the lowest quartile of the omega-3 index, declined cognitive measures, and greater risks of dementia. The omega-3 index may be used to identify persons at risk of dementia and that raising the index may lower the rate of cognitive decline. To date, findings from trials investigating the effects of omega-3 supplementation on cognitive outcomes have not been convincing. A question remains of whether omega-3 supplementation, especially targeting those in the lowest omega-3 index, could result in cognitive benefits.