Polyphenols & Immunity
Immune dysfunction is caused by various factors, including changes in relevant immune regulators due to invading pathogens and environmental stress.
Nutrition plays an essential role in immunity by interfering with immune biological activities, like proinflammatory molecules synthesis, immune cell regulation, and gene expression.
Polyphenols, a group of natural phytochemicals, promote immunity to foreign pathogens via various pathways. Different immune cells express multiple polyphenol receptors that recognize and allow cellular uptake of polyphenols, which subsequently activate signaling pathways to initiate immune responses.
Polyphenols have been shown to alleviate inflammation by reducing the production of pro-inflammatory mediators and increasing that of the anti-inflammatory mediators1.
Polyphenols are also shown to regulate immune cell functions at the epigenetic levels1.
Posted on 30 July 2021