Impact of Habitual Sedentary Patterns in Healthy Adults
Prolonged sitting attenuates lower-limb arterial endothelial-dependent vasodilation. In layman's terms, the blood supply to the lower limbs may be impaired. However, the impact of habitual sedentary patterns on lower-limb artery endothelial health is unclear.
A group of scientists tested the hypothesis on 98 healthy participants (age 19–77 years, 53 females) that greater habitual total sedentary time, more time spent in prolonged sedentary bouts, and fewer sedentary breaks would be associated with worse popliteal artery (an artery in the knee) flow-mediated dilation responses (the ability of the blood vessel to expand upon stimulation). The results suggested that habitual prolonged sedentary bouts and sedentary breaks, but not total sedentary time, were predictors of popliteal endothelial-dependent vasodilatory function. The scientists concluded that patterns by which sedentary time is accumulated might be more important than the total sedentary time on lower-limb arterial health.
While reducing the sedentary hours, we should also break them into shorter durations or bouts.
 Shivgulam, Madeline E, O’Brien, Myles W, Johns, Jarrett A, Petterson, Jennifer L, Wu, Yanlin, Frayne, Ryan J & Kimmerly, Derek S. Impact of habitual sedentary patterns on popliteal artery endothelial-dependent vasodilation in healthy adults. Vascular Medicine 0: 1358863X211065494.