How do polyphenols benefit our gut health?
Oxidative damage refers to the damage of cellular components, like proteins, DNA, and membranes, arising from the disturbances in cellular redox potential when elevated levels of reactive oxygen species (ROS) from host defense mechanisms are not counterbalanced.
The human gut is a major source of ROS. These ROS present an abusive, pro-oxidation environment which may be deleterious towards the gut microbiota. Oxidative stress is implicated for various pathophysiological diseases of the gut like inflammatory bowel disease and Irritable Bowel Syndromes. Combating oxidative stress generated in the gut may be instrumental in preventing the pathogenesis of different gut-related diseases.
Dietary polyphenols are phytochemicals naturally present in plants. They are shown to interact extensively with the gut microbiota.
Recent studies demonstrate that polyphenols increase the relative abundance of gut bifidobacteria and lactobacilli (good gut bacteria), and thereby modulate the human gut microbiota towards a more ‘health-promoting profile’.
The colon microbiota also participate in transforming 95% of dietary polyphenols into absorbable biologically active species. The mechanisms of action are likely to involve the antioxidant and anti-inflammatory properties of polyphenols.
Posted on 6 August, 2021