Antioxidants on Sperm Quality
Antioxidant supplementation has been identified as an essential intervention for subfertile men. However, the effectiveness of different antioxidants in improving sperm quality remains unclear.
A recently published network meta-analysis was designed to evaluate the effects of different antioxidants on sperm quality parameters in subfertile men. Published randomized controlled trials (RCTs) of antioxidants in subfertile men were searched in the PubMed, Embase, and Cochrane Library databases from inception to 31 January 2021. Eighteen published randomized controlled trials involving eight antioxidants (folic acid, zinc, vitamin E, carnitine, selenium, coenzyme q10 [CoQ10], N-acetylcysteine, and vitamin C) and 1790 subfertile men were included. CoQ10 elicited a significant increase in sperm concentration compared with the placebo; and achieved the highest rank in efficacy among all the antioxidants. Carnitine and CoQ10 showed substantial beneficial effects on sperm motility compared with the placebo, and the effectiveness of carnitine was the highest among all the antioxidants. The efficacy of vitamin C toward sperm morphology tended to be the highest, although it did not show a significant beneficial effect compared with the placebo. For subfertile men, CoQ10 and carnitine interventions showed better effectiveness in increasing sperm concentration and sperm motility, respectively.
The information may prove helpful for couples who want to be parents! Good luck!
1 Su, Liang, Qu, Hua, Cao, Yan, Zhu, Jian, Zhang, Si-zheng, Wu, Jie & Jiao, Yong-zheng. 2021. Effect of Antioxidants on Sperm Quality Parameters in Subfertile Men: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Advances in Nutrition 13: 586-594.